Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1205-71-6, name is 4-Chloro-N-phenylaniline, A new synthetic method of this compound is introduced below., Formula: C12H10ClN
General procedure: 0.248 g (1.00 mmol) of (4-bromophenyl) phenylamine, 0.176 g (1.05 mmol) of 9H-carbazole,4.6 mg (5.0 mumol) of tris (dibenzylideneacetone) dipalladium,14.9 mg (35.0 mumol) of 2- (di-tert-butylphosphino) -2 ‘, 4′, 6′-triisopropyl-1,1’-biphenyl,After 0.144 g (1.50 mmol) of sodium tert-butoxide and 3 mL of o-xylene were added, the inside of the reaction system was replaced with argon gas.Thereafter, the mixture was heated to 140 C. and stirred for 15 hours. After cooling to room temperature, the reaction was stopped by adding 25 mL of water. Further, 20 mL of ethyl acetate and 9- (p-tolyl) -9H-carbazole as an internal standard were added and stirred until the ethyl acetate layer became homogeneous.The ethyl acetate layer (0.2 mL) was collected, diluted with tetrahydrofuran 4 mL, and the conversion of (4-bromophenyl) phenylamine was 99% or more by HPLC analysis,It was confirmed that 98% of 9- [4- (phenylamino) phenyl] -9H-carbazole was formed relative to (4-bromophenyl) phenylamine.
The synthetic route of 1205-71-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SAGAMI CHEMICAL RESEARCH INSTITUTE; TOSOH CORPORATION; YAMAKAWA, TETSU; OHTSUKA, YUKI; MIYAZAKI, TAKANORI; (28 pag.)JP2018/90563; (2018); A;,
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