Reference of 694-80-4, These common heterocyclic compound, 694-80-4, name is 1-Bromo-2-chlorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Add to Schlenk tubeN- (2-mercapto) acetamide(0.3 mmol, 50.1 mg), FeSO47H2O (0.06 mmol, 16.68 mg),1,10-lindolinol (0.06 mmol, 10.8 mg) andPotassium tert-butoxide (1.2 mmol, 134.4 mg)With nitrogen to protect the reaction system (pumping gas three times),1,2-dibromobenzene (0.45 mmol, 105.2 mg) and DMF (2 mL) were added to the reaction system with a syringe,Heated to 135 C,Stirring reaction 24hAfter completion of the reaction, the mixture was cooled to room temperature,20 mL of water was added and extracted three times with ether,The organic phase was washed with water, dried over anhydrous sodium sulfate,Column chromatography to obtain the product10H-phenothiazine. Yield 70%.Using a method similar to that of Example 1,Respectively, with o-bromobenzene,O-bromochlorobenzene,O-chlorobenzene,O-dichlorobenzene was used in place of o-dibromobenzene in Example 1 to give the product phenothiazine in a yield of 72%, 81%80%, 20%.
Statistics shows that 1-Bromo-2-chlorobenzene is playing an increasingly important role. we look forward to future research findings about 694-80-4.
Reference:
Patent; Suzhou University; Zhang, Songlin; Hu, Weiye; Zheng, Songlin; Wu, San; Wang, Ru; Zhang, Fang; (7 pag.)CN104311508; (2017); B;,
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