Synthetic Route of 13726-14-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13726-14-2 name is 4-Chloro-3-methoxyaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A solution of 4-chloro-3-methoxy-aniline (7.00 g, 44.4 mmol) dissolved in dichloromethane (100 mL) at 5 C was treated portions with NBS (8.14 g, 45.7 mmol) over 1 hour, then warmed to 20 C and stirred at 20 C for 2 hours. On completion, a 5% aqueous Na2SO3 solution (100 mL) was added and the mixture was stirred for 10 minutes. The layers were separated and the organic layer was washed with water and saturated brine, dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The getting residue was purified by column chromatography (petroleum ether: ethyl acetate = 3:1) to give the title compound (9.00 g, 85% yield) as a dark brown solid.1H NMR (400MHz, CD3Cl) delta = 7.37 (s, 1H), 6.35 (s, 1H), 4.13 (br. s., 2H), 3.83 (s, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Chloro-3-methoxyaniline, and friends who are interested can also refer to it.
Reference:
Patent; RAZE THERAPEUTICS, INC.; MAINOLFI, Nello; (215 pag.)WO2018/106636; (2018); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics