Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 38762-41-3, name is 4-Bromo-2-chloroaniline, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H5BrClN
2-Fluoro-4-bromoaniline (3.83 g, 18.55 mmol) was added to a reaction flask, then anhydrous tetrahydrofuran (20 ml) was added, and the mixture was cooled to -78 C with a dry ice ethanol bath, and LiHMDS (55.65 ml, 55.65 mmol), after reacting at -78 C for 30 minutes, methyl 2-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate (4.00) was added. g, 18.55 mmol), after completion, the reaction was stirred at -78 C for 1 hour. After the completion of the reaction, the mixture was stirred at room temperature, and the reaction was quenched with saturated aqueous ammonium chloride.Column chromatography to obtain compounds(6.0 g, yield: 83.9%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BINJIANG PHARMA INC; Tianjin Binjiang Pharmaceutical Research And Development Co., Ltd.; TIAN HONGQI; Tian Hongqi; (39 pag.)CN109988105; (2019); A;,
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