Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1996-30-1, name is 3-Bromo-4-fluorochlorobenzene, A new synthetic method of this compound is introduced below., Computed Properties of C6H3BrClF
Example 9: 4- [3- (5-Chloro-2-fluoro-phenyl)-prop-2-ynyl]-piperazine-1- carboxylic acid ethyl ester; 4-Prop-2-ynyl-piperazine-1-carboxylic acid ethyl ester (0.22 g, 0.96 mmol), 2-bromo- 1-chloro-1-fluorobenzene (0.14 mL, 1.2 mmol) and diisopropylamine (0.17 mL, 1.2 mmol) were dissolved in dioxane (1 mL), and the solution degassed with argon for -10 minutes. Bis (methylcyanate) palladium (II) chloride (12 mg, 0.05 mmol), copper iodide (4 mg, 0.02 mmol) and tri-tert-butylphosphine (0.014 mL, 0.06 mmol) were added, and the reaction was sealed and allowed to stir for 16 h. Reaction mixture was diluted with EtOAc (5 mL) and filtered over celite using EtOAc. The organic layer was washed with NH4C1 solution (4 x 10 mL), then dried (Na2S04), filtered and concentrated onto silica gel. Chromatography (SPE) eluting with 30-50 % EtOAc/ hexanes afforded 113 mg (36 %) of the title compound as a yellow oil. 1H NMR (CDC13) 8 (ppm): 7.41 (dd, 1H), 7.26 (ddd, 1H), 7.02 (t, 1H), 4.16 (q, 2H), 3.60 (s, 2 H), 3.56 (t, 4H), 2.61 (t, 4H), 1.28 (t, 3H).
The synthetic route of 1996-30-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB?; NPS PHARMACEUTICALS, INC.; WO2005/80363; (2005); A1;,
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