In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 27139-97-5, name is 2-Bromo-4-chloro-1-methylbenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C7H6BrCl
EXAMPLE 10; (5-{2-r5-(S-Chloro-2-methylphenvl)hexahvdropyrrolor3.4-clpyrrol-2piH)-vn-13-thiazol-5-vU- 2H-tetrazol-2-yl)acetic acid; Step 1 tert-Butgamma\ 5-(5-chloro-2-methvlphenvpihexahgammadropyrrolo[3,4-clpyrrole-2(lH)- carboxylate; Into a 50 mL flask equipped a magnetic stir bar and a rubber septum was added tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(lH)-carboxylate oxalate (2 00 g, 6 62 mmol),10 palladium(II) acetate (149 mg, 0 66 mmol), racemic-B INAP (824 mg, 1 32 mmol) and sodium tert-butoxide (1 91 g, 19 9 mmol) The vial was evacuated under vacuum (10 mm Hg) and backfilled with N2 (repeated 3 times) Toluene (14 mL) and 2-bromo-4-chlorotoluene (2 18 g, 10 6 mmol) were added to the flask and the solvent was degassed for 10 mm with a steady flow of nitrogen before being heated to 115 0C for 20 h The reaction mixture was partitioned between15 EtOAc (200 mL) and water (150 mL) The aqueous layer was extracted with EtOAc (5 x 50 mL) and the combined organic layers were washed with brine, dried over Na?Spsi4 and concentrated The resulting pale brown oil was purified by column chromatography on silica gel, elutmg with 0percent EtOAc m hexanes to 40percent EtOAc m hexanes as a gradient The desired product was obtained as a yellow oil
The synthetic route of 27139-97-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK FROSST CANADA LTD.; LACHANCE, Nicolas; LEGER, Serge; OBALLA, Renata, M.; POWELL, David; TRANMER, Geoffrey, K.; MARTINS, Evelyn; GAREAU, Yves; WO2010/108268; (2010); A1;,
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