Adding a certain compound to certain chemical reactions, such as: 2533-69-9, name is Methyl 2,2,2-trichloroacetimidate, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2533-69-9, Product Details of 2533-69-9
Put the compound (1,2-phenylenediamine) (2 g, 10 mmol) shown in Formula 3 at room temperature,Add acetic acid (20mL) to the reaction flask, cool in an ice bath, and slowly add the compound shown in Formula 1 (2,2,2-trichloroimino to methyl acetate) (1.3mL, 10mmol) as the starting material.After the addition was complete, the mixture was stirred at room temperature for 1 hour. TLC showed that the reaction was complete.Saturated sodium bicarbonate solution neutralized excess acid, extracted with ethyl acetate,Dry over anhydrous sodium sulfate, filter,Concentration gave the compound (2-trichloromethyl-benzopyrimidine) represented by Formula 3 (2.6 g, 60%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2,2,2-trichloroacetimidate, and friends who are interested can also refer to it.
Reference:
Patent; Sun Yat-sen University; Fu Jiasheng; Lu Paxiama; G .leikexima Leidi; Hu Wenhao; Wang Xin; Huang Jiawu; Lin Zebin; (22 pag.)CN110606850; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics