In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 75717-77-0 as follows. Product Details of 75717-77-0
General procedure: A solution of 3-azido-1-tert-butyl-3-nitro-azetidine 5 (995 mg, 5 mmol) and substituted acetylene (c-k) (5.25 mmol.) in THF (40 ml) was treated at room temperature by adding a solution of ascorbic acid (440 mg, 2.5 mmol) in water (20 ml), followed by a solution of CuSO4¡¤5H2O (188 mg, 0.75 mmol) in water (10 ml). The reaction mixture was stirred for 2-6 h at room temperature. After the reaction was complete according to TLC, the mixture was diluted with water (20 ml) and extracted with CH2Cl2 (4¡Á20 ml). The organic layer was dried over Na2SO4, the solvent was removed at reduced pressure, and the residue was purified by flash chromatography (EtOAc/n-hexane, 2:3) to give the desired products 6c-k as colorless solids.
According to the analysis of related databases, 75717-77-0, the application of this compound in the production field has become more and more popular.
Reference:
Article; Dubovis, Mikhail V.; Rudakov, Gennady F.; Kulagin, Alexander S.; Tsarkova, Kseniya V.; Popkov, Sergey V.; Goloveshkin, Alexander S.; Cherkaev, Georgiy V.; Tetrahedron; vol. 74; 6; (2018); p. 672 – 683;,
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