Some common heterocyclic compound, 1871-57-4, name is 3-Chloro-2-chloromethyl-1-propene, molecular formula is C4H6Cl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1871-57-4
Sodium hydride (992.6 mg, 60% in mineral oil, 24.8 MMOL) was added portionwise to a solution of (2-hydroxy-ethyl)-carbamic acid test-butyl ester (2 g, 12.4 MMOL) in 1-methyl-2- pyrrolidinone (20 ML) AT-2 C, in order to maintain the temperature BELOW 5 C. The mixture was then stirred for 30 minutes, cooled TO-5 C, and a solution of 3-chloro-2-chloromethyl- 1-propene (1.44 ml, 12.4 MMOL) in 1-methyl-2-pyrrolidinone (10 ml) added dropwise in order to maintain the temperature below 3 C. Once addition was complete, the reaction mixture was allowed to warm to room temperature and stirred for a further 18 hours. The reaction mixture was diluted with water and extracted with ether (2X50 ml). The combined organic extracts were dried over magnesium sulphate and evaporated under reduced pressure. The residual oil was purified by column chromatography on silica gel using ethyl acetate: pentane (10: 90) to give the title compound as a clear oil, 713 mg. H NMR (400MHZ, CDCI3) : No. 1. 46 (s, 9H), 3.51 (d, 2H), 3.72 (d, 2H), 4.00-4. 20 (m, 4H), 4.95 (s, 1H), 5.04 (s, 1H). APCI M/Z 236 [MNA] +
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1871-57-4, its application will become more common.
Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/74291; (2004); A1;,
Chloride – Wikipedia,
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