In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6940-78-9 as follows. 6940-78-9
Methanol (149 L), 7-hydroxy-1H-quinolin-2-one (14.87kg), and potassium hydroxide (6.21 kg) were mixed and stirred.After dissolution, 1-bromo-4-chlorobutane (47.46 kg) was further added thereto and the resulting mixture was stirred under reflux for seven hours. Thereafter, the mixture was stirred at 10C forone hour. The precipitated crystal was centrifuged and washed with methanol (15 L). The wet crystal was collected and placed ina tank. Water (149 L) was added thereto, followed by stirring atroom temperature. After centrifugation, the resulting solid was washed with water (30 L). The wet crystal was collected andplaced in a tank. After adding methanol (74 L), the mixture was stirred under reflux for one hour, cooled to 10C, and thenstirred. The precipitated crystal was centrifuged and washed withmethanol (15 L). The separated crystal was dried at 60C to obtain 7-(4-chlorobutoxy)-1H-quinolin-2-one (15.07 kg).
According to the analysis of related databases, 6940-78-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; OTSUKA PHARMACEUTICAL CO., LTD.; YAMASHITA, Hiroshi; SATO, Tetsuya; MINOWA, Takuya; HOSHIKA, Yusuke; TOYOFUKU, Hidekazu; YAMAGUCHI, Tatsuya; SOTA, Masahiro; KAWANO, Shuuji; NAKAMURA, Takayuki; ETO, Ryohei; IKEBUCHI, Takuma; MORIYAMA, Kei; ITO, Nobuaki; WO2013/162046; (2013); A1;,
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