Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27139-97-5, name is 2-Bromo-4-chloro-1-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., 27139-97-5
The cooling pipe is attached, the container is again after replacing the argon, distilled water (30 ml), 2-bromo-4-chlorotoluene (5. 23g, 20. 5mmol), tetrakistriphenyl phosphinepalladium (0. 462g, 0. 40mmol), potassium carbonate (2. 76g, 20mmol), and toluene (100 ml) is added, which is circulated to 5 hours. After cooling to room temperature, transferring the liquid content scopolia, organic phase and aqueous phase is separated, the water phase is removed, washed with organic phase. By drying the organic phase is sodium sulfate. Thereafter, by filtration to remove sodium sulfate, organic phase is concentrated. The mixture is purified by silica gel column chromatography (developing solvent: Phenylbicyclohexane), and the purpose of the above chemical eq. (118) is obtained (yield 4. 14g, yield 82. 4percent)
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Reference:
Patent; NIPPON HOSO KYOKAI <NHK>; KANTO CHEM CO INC; FUKAGAWA HIROHIKO; SHIMIZU TAKAHISA; TAKAHASHI JUNPEI; SHINNAI SATONOBU; TSUCHIYA KAZUHIKO; (53 pag.)JP2015/160849; (2015); A;,
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