Sulfonyliminoimidazolidines. A new class of oral hypoglycemic agents. 1. 1-[[p-[2-(Acylamino)ethyl]phenyl]sulfonyl]-2-iminoimidazolidines was written by Schweizer, Ernst H.;Maerki, Fritz;Lehmann, Claude;Dietrich, Henri. And the article was included in Journal of Medicinal Chemistry in 1983.SDS of cas: 3438-16-2 This article mentions the following:
A series of 1-[[p-[2-(acylamino)ethyl]phenyl]sulfonyl]-2-iminoimidazolidines were prepared from I (R = H). Compounds from this new class of oral hypoglycemic agents lowered blood glucose in normal and in streptozotocin-diabetic rats. Potent analogs were obtained by modification of the acyl residue. I (R = trans-MeCH:CHCO) was the most potent compound in the normal rat (20 times tolbutamide), and I (R = 5-methyl)-3-isoxazolylcarbonyl) displayed the highest potency in the diabetic rat (similar to phenformin). Structure-activity relationships were discussed. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2SDS of cas: 3438-16-2).
5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).SDS of cas: 3438-16-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics