Synthesis and biological evaluation of thieno[3,2-d]pyrimidinones, thieno[3,2-d]pyrimidines and quinazolinones: conformationally restricted 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors was written by Perspicace, Enrico;Marchais-Oberwinkler, Sandrine;Hartmann, Rolf W.. And the article was included in Molecules in 2013.Formula: C9H9ClO2 This article mentions the following:
In this study, a series of conformationally restricted thieno[3,2-d]pyrimidinone derivatives, thieno[3,2-d]pyrimidine derivatives and quinazolinone derivatives was designed and synthesized with the goal of improving the biol. activity as 17β-hydroxysteroid dehydrogenase type 2 inhibitors of the corresponding amidothiophene derivatives Two moderately active compounds were discovered and this allowed the identification of the biol. active open conformer as well as the extension of the enzyme binding site characterization. The title compounds thus formed included a thienopyrimidine derivative (I) and related substances, such as quinazoline analogs. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Formula: C9H9ClO2).
2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Formula: C9H9ClO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics