Synthesis of new 1,4- and 1,5-disubstituted N-ethyl acetate and N-α-butyro-γ-lactone alkylimidazole derivatives as N-acylhomoserine lactone analogs was written by Qiang, Zhang;Li, Si-Zhe;Queneau, Yves;Soulere, Laurent. And the article was included in Journal of Heterocyclic Chemistry in 2021.Recommanded Product: (Chloromethanetriyl)tribenzene This article mentions the following:
New alkylimidazoles functionalized with a homoserine lactone or an alkyloxycarbonyl moiety was synthesized as N-acylhomoserine lactones (AHLs) analogs. The 1,4-disubstituted imidazole derivatives were prepared by alkylation of 4(5)-alkylimidazoles with α-bromo-γ-butyrolactone or Et α-bromoacetate. An alternative route was preferred for the synthesis of their 1,5-disubstituted counterparts based on the use of a N1-protected alkylimidazole, its alkylation to an N3-imidazolyl-α-acetate and deprotection to the desired 1,5-disubstituted esters and subsequent alkylation of the acetate moiety with cyclic ethylene sulfate followed by acid-catalyzed cyclization. The ability to modulate bacterial quorum sensing of all new compounds was compared to that of previously reported AHL analogs in which the amide bond is replaced by a heterocyclic group. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Recommanded Product: (Chloromethanetriyl)tribenzene).
(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: (Chloromethanetriyl)tribenzene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics