Thiosemicarbazide, a fragment with promising indolamine-2,3-dioxygenase (IDO) inhibition properties was written by Serra, Silvia;Moineaux, Laurence;Vancraeynest, Christelle;Masereel, Bernard;Wouters, Johan;Pochet, Lionel;Frederick, Raphael. And the article was included in European Journal of Medicinal Chemistry in 2014.Product Details of 6590-96-1 This article mentions the following:
With the aim to explore the interest of the thiosemicarbazide scaffold for the inhibition of the indoleamine 2,3-dioxygenase (IDO), a promising therapeutic target for anticancer immunotherapy, a series of 32 phenylthiosemicarbazide derivatives was prepared and their IDO inhibition evaluated. Our study demonstrated that among these derivatives, compound I characterized with a 4-cyanophenyl group on the thiosemicarbazide was the more potent IDO inhibitor in this series being endowed with an IC50 of 1.2 μM. The SAR depicted showed that substitution in the 3- and 4-position relative to the phenylthiosemicarbazide are very promising whereas substitution in the 2-position always leads to less potent or inactive derivatives In fact, the study highlighted a novel interesting scaffold for IDO inhibition for further development. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Product Details of 6590-96-1).
2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Product Details of 6590-96-1
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics