Design and synthesis of novel 1,3,4-oxadiazole sulfone compounds containing 3,4-dichloroisothiazolylamide moiety and evaluation of rice bacterial activity was written by Xiang, Jie;Liu, Dengyue;Chen, Jixiang;Hu, Deyu;Song, Baoan. And the article was included in Pesticide Biochemistry and Physiology in 2020.SDS of cas: 620-19-9 This article mentions the following:
In this study, thirty 1,3,4-oxadiazole sulfone derivatives containing 3,4-dichloroisothiazolamide moiety I [X = CH2, R1 = H, Me; X = CH2CH2, R1 = H; R2 = Me, i-Pr, PhCH2, thiophen-3-ylmethyl, etc.] were designed and synthesized and their antibacterial activities were evaluated. Bioassay results showed that some compounds exhibited excellent antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas oryzae pv. oryzicola (Xoc) in vitro and in vivo. Notably, the EC50 values of compounds I (X = CH2; R1 = H; R2 = Et, n-Pr) against Xoo were 0.79 and 0.85μg/mL, resp., which were superior to those of the control agents isotianil, bismerthiazol and thiodiazole copper. In addition, in vivo antibacterial activities revealed that the compound I (X = CH2; R1 = H; R2 = Et) at 50μg/mL possessed protective and curative activities of 43.99% and 41.06% against Xoo, resp., which were better than pos. controls. Furthermore, the preliminary mechanism study disclosed that this compound exhibited effective antibacterial activity against Xoo by inhibiting the formation of extracellular polysaccharides from Xoo, increasing cell permeability and changing the shape of cells. This study suggested that 1,3,4-oxadiazole sulfone derivatives containing 3,4-dichloroisothiazolamide moiety displayed excellent antibacterial activity and could be further explored and developed as com. pesticides. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9SDS of cas: 620-19-9).
1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.SDS of cas: 620-19-9
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics