Wagner-Jaurego, Theodor et al. published their research in Technische Hochschule, Zurich. Helv. Chim. Acta in 1929 | CAS: 7476-66-6

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Safety of Methyl 2-chloro-2-phenylacetate

Replacement by chlorine of the hydroxyl group in esters of hydroxy acids by means of phosphorus oxychloride and pyridine (steric course of the substitution) was written by Wagner-Jaurego, Theodor. And the article was included in Technische Hochschule, Zurich. Helv. Chim. Acta in 1929.Safety of Methyl 2-chloro-2-phenylacetate This article mentions the following:

POCl3 can be used to replace OH by Cl in HO acids, provided pyridine is present. In its absence, dehydration often occurs. The chlorination is often accompanied by a reversal in polarity of the optically active acids d-Chlorosuccinic ester is prepared by treating 12.2 g. of l-malic acid (αD16.6 -4.62°) and 11.9 g. pyridine with 11.5g. of cold POCl3, allowing to stand for 1 hr. in a freezing mixture After 22 hrs.’ standing at room temperature, the mass is decomposition with H2O and extracted with CHCl3. The extract is washed with H2O, dried with Na2SO4 and distilled It b16, 110-1° (yield 4.8 g.). After refractionation it b10-1 106-7° (uncorrected), αD20 +36.6°. Me phenylchloroacetate: 7.4 g. of d-mandelic acid, αD18 (CS2) 172 (pure acid: 214°) + 7.1 g. pyridine + 6.8 g, POCl3 yielded 4.2 g. b19-20 133-40°. After refractionation it b.15.5-14 130-1 (corrected) αD18-62.2° (calculated for optically pure product -77.4°) dl-Isomer: 12.5 g. di-mandelic acid + 12 g. pyridine + 11.5 g. POCl3 gave 6.8 g. of dl-product; b13-15 129-30° (corrected). In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Safety of Methyl 2-chloro-2-phenylacetate).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Safety of Methyl 2-chloro-2-phenylacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics