The chemical industry reduces the impact on the environment during synthesis 933190-51-3, name is 8-Bromo-6-chloroimidazo[1,2-b]pyridazine, I believe this compound will play a more active role in future production and life. 933190-51-3
A mixture of 8-bromo-6-chloroimidazo[l ,2-b]pyridazine (300 mg, 1.3 mmol), 6-(3- methylcyclopentyl)pyridin-2-amine (277 mg, 1.56 mmol), Pd2(dba)3 (75 mg, 0.13 mmol), BINAP (324 mg, 0.52 mmol), Cs2C03 (1272 mg, 3.9 mmol) and dioxane (20 mL) was heated to 100 C with stirring for 16 h under N2. The solvent was removed in vacuo and the resulting mixture was purified by chromatography (silica gel, 200 – 300 mesh, petroleum ether : ethyl acetate = 5 : 1) to give 6-chloro-N-(6-(3-methylpyrrolidin-l-yl)pyridin-2-yl)imidazo[l ,2-b] pyridazin-8-amine (301 mg, 70 %) as a yellow solid. LC-MS : [M+H]+, 329.1 , tR = 1.949min.
The chemical industry reduces the impact on the environment during synthesis 933190-51-3. I believe this compound will play a more active role in future production and life.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HERMANN, Johannes Cornelius; KUGLSTATTER, Andreas; LUCAS, Matthew C.; PADILLA, Fernando; WANNER, Jutta; ZHANG, Xiaohu; WO2013/64445; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics