Trichloroisocyanuric acid oxidation of 2-chloro aldehyde acetals to 2-chloro acid esters was written by Boni, Monica;Ghelfi, Franco;Pagnoni, Ugo Maria;Pinetti, Adriano. And the article was included in Bulletin of the Chemical Society of Japan in 1994.Application In Synthesis of Methyl 2-chloro-2-phenylacetate This article mentions the following:
2-Chloro acid Me esters were prepared in good yields by treating 2-chloro aldehyde di-Me acetals with trichloroisocyanuric acid in DMF. Aldehyde di-Me acetals with the 2-halogen on a tertiary carbon atom were poorly reactive and could be oxidized efficiently only after their transformation into 1,3-dioxolanes. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Application In Synthesis of Methyl 2-chloro-2-phenylacetate).
Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application In Synthesis of Methyl 2-chloro-2-phenylacetate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics