Synthesis and in vitro anti-Helicobacter pylori activity of 2-(substituted benzylthio)-5-(5-nitro-2-furyl)-1,3,4-thiadiazole derivatives was written by Mohammadhosseini, Negar;Asadipour, Ali;Letafat, Bahram;Vosooghi, Mohsen;Siavoshi, Farideh;Shafiee, Abbas;Foroumadi, Alireza. And the article was included in Turkish Journal of Chemistry in 2009.Product Details of 697-73-4 This article mentions the following:
Starting from (5-nitrofuran-2-yl)methylene diacetate, a series of 2-[(substituted benzyl)thio]-5-(5-nitro-2-furyl)-1,3,4-thiadiazoles were synthesized and characterized. The in vitro anti-Helicobacter pylori activity of the synthesized compounds was evaluated by the disk diffusion method against the clin. isolates of Helicobacter pylori. The results indicated that most of the synthesized compounds exhibited significant inhibitory activity against H. pylori with respect to standard drug metronidazole. Compound I, containing the 2-chloro-6-fluorobenzylthio moiety, was the most potent compound tested. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Product Details of 697-73-4).
2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Product Details of 697-73-4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics