Development of lipophilic prodrugs of mitomycin C. III. Physicochemical and biological properties of newly synthesized alkoxycarbonyl derivatives was written by Sasaki, Hitoshi;Fukumoto, Mari;Hashida, Mitsuru;Kimura, Toshikiro;Sezaki, Hitoshi. And the article was included in Chemical & Pharmaceutical Bulletin in 1983.Application of 57045-82-6 This article mentions the following:
Five alkoxycarbonyl derivatives of mitomycin C possessing various lipophilic promoieties including benzyloxycarbonyl [86476-06-4], propyloxycarbonyl [88700-49-6], pentyloxycarbonyl [88700-50-9], nonyloxycarbonyl [88700-51-0] and cholesteryloxycarbonylmitomycin C [88700-48-5] were synthesized and their physicochem. and biol. characteristics were examined All compounds showed increases of octanol/water partition coefficients, lipophilic indexes (k0) in high-performance liquid chromatog. and lipid solubilities to various degrees depending on their promoiety structure. The prodrugs showed increased lipohilicity with increase in the length of the alkyl chain. They showed only slight antimicrobial activities against Escherichia coli B, but all the compounds except for cholesteryloxycarbonyl mitomycin C showed significant activity in vivo against a L1210 leukemia system at a relatively low dose range. These derivatives showed enzyme-mediated conversion to the parent compound in rat plasma and liver homogenate, while they were chem. stable in neutral aqueous media. Essentially no bioactivation was observed for cholesteryloxycarbonyl mitomycin C. Species differences were observed in these bioactivation phenomena. These results suggested the potential utility of the derivatives as lipophilic prodrugs. In the experiment, the researchers used many compounds, for example, Chloroformicacidn-nonylester (cas: 57045-82-6Application of 57045-82-6).
Chloroformicacidn-nonylester (cas: 57045-82-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 57045-82-6
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics