Catalytic reductive desymmetrization of malonic esters was written by Xu, Pengwei;Huang, Zhongxing. And the article was included in Nature Chemistry in 2021.Application of 5335-05-7 This article mentions the following:
Here, a dinuclear zinc complex with a tetradentate ligand could selectively hydrosilylate one of the carbonyls of malonic esters to give α-quaternary β-hydroxyesters I [R1 = Me, CH2F, allyl, etc.; R2 = Ph, 3-thienyl, 1-naphthyl, etc.] was reported, providing a promising alternative to the desym. hydrolysis using carboxylesterases. The asym. reduction features excellent enantiocontrol that could differentiate sterically similar substituents and high chemoselectivity toward the diester motif of substrates. Together with the versatile preparation of malonic ester substrates and post-reduction derivatization, the desym. reduction had enabled the synthesis of a diverse array of quaternary stereocenters with distinct structural features. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Application of 5335-05-7).
Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 5335-05-7
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics