Mach, Robert H. et al. published their research in Medicinal Chemistry Research in 1999 | CAS: 3438-16-2

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of 5-Chloro-2-methoxybenzoic acid

Structure-activity relationship studies of N-(9-benzyl)-9-azabicyclo[3.3.1]nonan-3β-yl benzamide analogues for dopamine D2 and D3 receptors was written by Mach, Robert H.;Hammond, Philip S.;Huang, Yunsheng;Yang, Biao;Xu, Yueping;Cheney, Jason T.;Freeman, Rebekah;Luedtke, Robert R.. And the article was included in Medicinal Chemistry Research in 1999.Application In Synthesis of 5-Chloro-2-methoxybenzoic acid This article mentions the following:

A series of benzamide derivatives such as I (R = H, HO, MeO, MeS, O2N; R1 = H, Me, MeO; R2 = H, Cl; R3 = H, Br, Cl, I, Me, O2N; R4 = H, Br) were prepared in order to determine the nature of the substituent effects in the benzamide aromatic ring on the affinity to dopamine D2 and D3 receptors. Both quant. structure-activity relationship and mol. modeling (CoMFA) studies were conducted in order to identify the properties of the substituents important for receptor binding. Although traditional QSAR studies provided nearly identical equations for D2 and D3 receptor binding, CoMFA anal. indicated that there are subtle differences in both the steric and electronic properties of the D2 and D3 receptor in the region of the receptor recognizing the benzamide aromatic ring. 2,3-Disubstituted benzamides are favored for binding to dopamine D2 and D3 receptors; substitution in the 3-position of the benzamides yields compounds selective for the dopamine D2 receptor. These data should provide useful information in the design of second-generation analogs possessing a higher affinity for D3 vs. D2 receptors. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Application In Synthesis of 5-Chloro-2-methoxybenzoic acid).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of 5-Chloro-2-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics