Pd(II)-catalysed meta-C-H functionalizations of benzoic acid derivatives was written by Li, Shangda;Cai, Lei;Ji, Huafang;Yang, Long;Li, Gang. And the article was included in Nature Communications in 2016.Application In Synthesis of 3-Chloro-2,6-difluorobenzoic acid This article mentions the following:
Herein, a general protocol for meta-C-H olefination of benzoic acid derivatives using a nitrile-based sulfonamide template is reported. A broad range of benzoic acid derivatives are meta-selectively olefinated using mol. oxygen as the terminal oxidant. The meta-C-H acetoxylation, product of which is further transformed at the meta-position, is also reported. In the experiment, the researchers used many compounds, for example, 3-Chloro-2,6-difluorobenzoic acid (cas: 225104-76-7Application In Synthesis of 3-Chloro-2,6-difluorobenzoic acid).
3-Chloro-2,6-difluorobenzoic acid (cas: 225104-76-7) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application In Synthesis of 3-Chloro-2,6-difluorobenzoic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics