Covalently Immobilizable Tris(Pyridino)-Crown Ether for Separation of Amines Based on Their Degree of Substitution was written by Vezse, Panna;Benda, Bianka;Fekete, Andras;Golcs, Adam;Toth, Tunde;Huszthy, Peter. And the article was included in Molecules in 2022.Synthetic Route of C19H15Cl This article mentions the following:
A great number of biol. active compounds contain at least one amine function. Appropriate selectivity can only be accomplished in a few cases upon the substitution of these groups, thus functionalization of amines generally results in a mixture of them. The separation of these derivatives with very similar characteristics can only be performed on a preparative scale or by applying pre-optimized HPLC methods. A tris(pyridino)-crown ether was designed and synthesized for overcoming these limitations at a mol. level. It is demonstrated, that this selector mol. is able to distinguish protonated primary, secondary and tertiary amines by the formation of reversible complexes with different stabilities. This degree of substitution-specific mol. recognition of amines opens the door to develop separation processes primarily focusing on the purification of biol. active compounds in a nanomolar scale. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Synthetic Route of C19H15Cl).
(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Synthetic Route of C19H15Cl
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics