Copper-/Silver-Mediated Arylation of C(sp2)-H Bonds with 2-Thiophenecarboxylic Acids was written by Zhao, Sheng;Liu, Yue-Jin;Yan, Sheng-Yi;Chen, Fa-Jie;Zhang, Zhuo-Zhuo;Shi, Bing-Feng. And the article was included in Organic Letters in 2015.Category: chlorides-buliding-blocks This article mentions the following:
A copper/silver-mediated arylation of (hetero)aryl C-H bonds with 2-thiophenecarboxylic acids has been achieved. E.g., in presence of CuOAc, AgNO3, and Li2CO3 in DMF, arylation of I with 2-thiophenecarboxylic acid gave 67% 2-fluoro-N-(2-(pyridin-2-yl)propan-2-yl)-2-(thiophen-2-yl)benzamide (II). The protocol features a broad substrate scope and high functional group tolerance. Preliminary mechanistic studies indicate that a cascade protodecarboxylation/dehydrogenative coupling process is likely involved. In the experiment, the researchers used many compounds, for example, 2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2Category: chlorides-buliding-blocks).
2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics