Synthesis of 1-Indanones from Benzoic Acids was written by Huang, Yun-Sheng;Liu, Jian-Qiang;Zhang, Lang-Jun;Lu, He-Lin. And the article was included in Industrial & Engineering Chemistry Research in 2012.Safety of 5-Chloro-2-methoxybenzoic acid This article mentions the following:
An improved process for the preparation of 1-indanones, e.g., I, from various benzoic acids is described. This process involves a Friedel-Crafts acylation between a substituted benzoyl chloride and ethylene, followed by an intramol. Friedel-Crafts alkylation in the presence of aluminum chloride. The described process combines three steps into a one-pot process, is scalable, is cost-effective, and thus has a general applicability in manufacturing production of various 1-indanones. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Safety of 5-Chloro-2-methoxybenzoic acid).
5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Safety of 5-Chloro-2-methoxybenzoic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics