Mechanosynthesis of pharmaceutically relevant sulfonyl-(thio)ureas was written by Tan, Davin;Strukil, Vjekoslav;Mottillo, Cristina;Friscic, Tomislav. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2014.Recommanded Product: 5-Chloro-2-methoxybenzoic acid This article mentions the following:
The authors demonstrate the first application of mechanochem. to conduct the synthesis of sulfonyl-(thio)ureas, including known anti-diabetic drugs tolbutamide, chlorpropamide and glibenclamide, in good to excellent isolated yields by either stoichiometric base-assisted or copper-catalyzed coupling of sulfonamides and iso(thio)cyanates. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Recommanded Product: 5-Chloro-2-methoxybenzoic acid).
5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 5-Chloro-2-methoxybenzoic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics