Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloro-quinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives was written by Cheng, Pi;Zhang, Quan;Ma, Yun-Bao;Jiang, Zhi-Yong;Zhang, Xue-Mei;Zhang, Feng-Xue;Chen, Ji-Jun. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Application of 18437-66-6 This article mentions the following:
A series of 4-aryl-6-chloro-quinolin-2-ones and 5-aryl-7-chloro-1,4-benzodiazepines were synthesized and assayed for their in vitro anti-hepatitis B virus activities and cytotoxicities. Some of the tested compounds were active against HBsAg and HBeAg secretion in Hep G2.2.15 cells. I [R = CH2CH2OH] showed IC50 of 0.074 and 0.449 mM on HBsAg and HBeAg secretions, resp., which were 10 times higher than that of its analog I [R = H] and led to better selective index (SI) values (SI = 23.2 and 3.4, resp.). In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Application of 18437-66-6).
tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application of 18437-66-6
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics