Novel synthesis of 4H-1,4-benzoxazines was written by Kudo, Noriaki;Furuta, Satoru;Sato, Kazuo. And the article was included in Chemical & Pharmaceutical Bulletin in 1996.Product Details of 85953-29-3 This article mentions the following:
The reaction of Me 2-chloro-5-ethoxycarbonylamino-4-fluorobenzoate (I) and 1-bromo-3,3-dimethyl-2-butanone in the presence of 2.2 equiv of LiN(SiMe3)2 afforded the 4H-1,4-benzoxazine II in good yield, instead of the expected 4-oxazolin-2-one III. Similar preparations of 5 addnl. benzoxazines are described. The generality of the reaction and the mechanism are discussed. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3Product Details of 85953-29-3).
Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Product Details of 85953-29-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics