Studies on the novel pyridine sulfide containing SDH based heterocyclic amide fungicide was written by Hua, Xuewen;Liu, Wenrui;Su, Yanyan;Liu, Xinghai;Liu, Jingbo;Liu, Nannan;Wang, Guiqing;Jiao, Xueqin;Fan, Xiaoyi;Xue, Chenmeng;Liu, Yi;Liu, Ming. And the article was included in Pest Management Science in 2020.HPLC of Formula: 59237-53-5 This article mentions the following:
BACKGROUND : Succinate dehydrogenase (SDH) has been identified as one of the most significant targets for fungicide discovery. To date, 23 com. SDH inhibitor (SDHI) fungicides have been approved for plant protection since the first launch of carboxin in 1966, and extensively applied to combat destructive plant fungi. RESULTS : In this project, 20 novel pyridine sulfide derivatives containing SDH-based heterocyclic amide fungicide were designed, synthesized, and characterized by proton NMR (1H-NMR), carbon-13 (13C)-NMR and high-resolution mass spectrometry (HRMS). In vitro fungicidal activity experiment, the target compound I-1 displayed excellent inhibitory rates against the common agricultural pathogens with half maximal effective concentration (EC50) values of 5.2 to 39.8μg mL-1. The in vivo fungicidal activities demonstrated that the compound I-1 could effectively prevent Botrytis cinerea from infecting tomato and cucumber leaves with the preventative rates of 67% and 50%. The mitochondrial membrane potential detection, SDH enzyme assay and the mol. docking simulation revealed that the mechanism of action of the compound I-1 and the relevant interactions with the target enzyme may be similar to those of the control fluopyram. CONCLUSION : The biol. activity screening and validation of mechanism of action indicated that the compound I-1 could be identified as a potential SDH inhibitor for further study. 2020 Society of Chem. Industry. In the experiment, the researchers used many compounds, for example, Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5HPLC of Formula: 59237-53-5).
Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.HPLC of Formula: 59237-53-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics