Identification of an aminothiazole series of RORβ modulators was written by Patouret, Remi;Doebelin, Christelle;Garcia-Ordonez, Ruben D.;Chang, Mi Ra;Ruiz, Claudia;Cameron, Michael D.;Griffin, Patrick R.;Kamenecka, Theodore M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.HPLC of Formula: 1711-11-1 This article mentions the following:
Crystallog. has identified stearic acid, ALRT 1550 and ATRA as ligands that bind RORβ, however, none of these mols. represent good starting points to develop optimized small mol. modulators. Recently, I was identified as a potent dual RORβ and RORγ inverse agonist with no activity towards RORα (Fig. 1). To the knowledge, this is one of only two small mol. RORβ inverse agonists identified in the primary literature from a tractable chem. series and represents an ideal starting point from which to design RORβ-selective modulators. Herein the authors describe the SAR optimization efforts that led to a series of potent neutral antagonists of RORβ. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1HPLC of Formula: 1711-11-1).
3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.HPLC of Formula: 1711-11-1
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics