Fluorinated pyrido[2,3-c]pyridazines. II. Synthesis and antibacterial activity of 1,7-disubstituted 6-fluoro-4(1H)-oxopyrido[2,3-c]pyridazine-3-carboxylic acids was written by Miyamoto, Teruyuki;Matsumoto, Junichi. And the article was included in Chemical & Pharmaceutical Bulletin in 1990.Recommanded Product: Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate This article mentions the following:
Chem. modification of pyridonecarboxylic acid antibacterials with a 1,8-naphthyridine ring, such as enoxacin and tosufloxacin, to their 2-aza derivatives was studied. A new series of 1,7-disubstituted fluorooxopyridopyridazines, e.g. I (R = Et, CH2CH2F, C6H4F-4, R1 = H, Me), was prepared by either alkylation of Et 6-fluoro-4(1H)-oxo-7-(p-tolylthio)pyrido[2,3-c]pyridazine-3-carboxylate or intramol. cyclization of Et 2-(2,6-dichloro-5-fluoronicotinoyl)-2-[2-(p-fluorophenyl)hydrazono]acetate, followed by displacement reaction with cyclic amines at C-7. Antibacterial activities of these compounds were markedly inferior to those of enoxacin and tosufloxacin. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Recommanded Product: Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate).
Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics