Dithiane-directed Rh(III)-catalyzed amidation of unactivated C(sp3)-H bonds was written by Shi, Heyao;Dixon, Darren J.. And the article was included in Chemical Science in 2019.Related Products of 6834-42-0 This article mentions the following:
An oxidant-free Rh(III)-catalyzed direct amidation of alkyl dithianes I (R1 = Me, Ph, PhCH2, MeO2C, etc., R2 = Me; R1R2 = CH2CH2NBocCH2CH2) via C(sp3)-H bond activation utilizing diverse and robust dioxazolone reagents II (R3 = t-BuCH2, cyclopropyl, n-undecyl, Ph, PhCH2, 2-furyl, etc.) is reported. The reaction hinges on use of a Cp*Rh(III) complex in combination with an essential amino-carboxylate additive to generate usefully protected 1,3-aminoaldehyde derivatives III. The scalability of the reaction was demonstrated as was a series of downstream product functionalizations, including dithiane deprotection, anion alkylation and reductive desulfurization, highlighting the general applicability of this transformation in the synthesis of novel scaffolds and building blocks. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Related Products of 6834-42-0).
2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 6834-42-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics