Copper-Catalyzed Alkylarylation of Unactivated Alkenes: Synthesis of 3-Alkyl Indolines from N-Allyl Anilines and Alkanes was written by Liang, Deqiang;Huo, Bojie;Dong, Yongrui;Wang, Yan;Dong, Ying;Wang, Baoling;Ma, Yinhai. And the article was included in Chemistry – An Asian Journal in 2019.Reference of 18437-66-6 This article mentions the following:
A rare example of C(sp3)-H functionalization of simple alkanes with unactivated alkenes was presented. In the presence of a copper salt and di-tert-Bu peroxide (DTBP), N-allyl anilines underwent exo-selective alkylation/cyclization cascade with unactivated alkenic bonds as radical acceptors and simple alkanes as radical precursors, providing a direct access to 3-alkyl indolines I [R = H, 5-Cl, 5-Ph, etc.; R1 = C(Me)2CH2CH3, cyclopentyl, cyclohexyl, etc.; R2 = C(O)Me, Boc, SO2Et, etc.]. The present protocol featured simple operation, broad substrate scope and great exo selectivity. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Reference of 18437-66-6).
tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Reference of 18437-66-6
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics