Asymmetric Synthesis of Spirooxazolidinone Oxindoles by the Thiourea-Catalyzed Aldol Reaction of 2-Isocyanatomalonate Diesters was written by Chen, Xiao-Pan;Liu, Jin-Xin;Li, Hong-Yan;Xiao, You-Cai;Chen, Fen-Er. And the article was included in Advanced Synthesis & Catalysis in 2022.Product Details of 76-83-5 This article mentions the following:
A tertiary amino-thiourea catalyzed asym. aldol reaction between 2-isocyanatomalonate esters and isatins was achieved. Optical active spirooxazolidinone oxindole derivatives I [R = Me, Bn, trityl, etc.; R1 = H, 4-Me, 5-i-Pr, etc.; R2 = Me, Et, Bn, etc.; X = C, N] were obtained with excellent yields (80%-96%) and enantioselectivities (67%-99% ee) under mild conditions, providing an updated example to apply isatins as the electrophile in the asym. aldol reaction with 2-isocyanatomalonate esters. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Product Details of 76-83-5).
(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Product Details of 76-83-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics