Eco-friendly construction of spiroquinazolin-2-(thi)ones and quinolin-(thio)ureas via Fe(III)-catalyzed multi-component domino double [4 + 2] annulations was written by Pan, Zhentao;Shi, Shuaijun;Yang, Xuancheng;Xiao, Xuqiong;Zhang, Wangqin;Wang, Shiliang;Ma, Yongmin. And the article was included in Green Chemistry in 2021.Quality Control of 2,4-Dichlorophenylisothiocyanate This article mentions the following:
An unprecedented eco-friendly multi-component domino approach for the synthesis of novel spiroquinazolin-2-(thi)ones I (X = O, S; R = H, Me; R1 = Me, Et; R2 = n-Pr, 4-fluorophenyl, 4-(ethoxycarbonyl)benzen-1-yl, etc.) and quinolin-(thio)ureas II (R3 = i-Pr, 2,4-dichlorophenyl, naphthalen-1-yl, etc.) is described. The protocol proceeds via domino double [4+2] annulations and features an eco-benign catalyst and solvent, simple starting materials, high atom-economy, H2O as the sole byproduct and a simple work-up procedure. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Quality Control of 2,4-Dichlorophenylisothiocyanate).
2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Quality Control of 2,4-Dichlorophenylisothiocyanate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics