Aromatic nucleophilic substitution. XI. Effect of meta substituents was written by Bevan, Cecil W. L.;Hirst, J.;Una, S. J.. And the article was included in Nigerian Journal of Science in 1966.Synthetic Route of C6H3ClFNO2 This article mentions the following:
Variation in the rates and log B factor in the Arrhenius equation K = BE-/RT are recorded and correlated largely with changes in activation energy. The compounds used are 3-(R-substituted)-5-nitrofluorobenzenes with methoxide ion in methanol, R being NH2, CO2-, Me3, tert-Bu, OMe3, H, Ac, F, I, Cl, Br, CF3, SO2Me, or NO2. OMe and NH2 groups induce deactivation whereas Ac induces (-T) effect in the mol. MeSO2 in the para position is 10 times less activating than the NO2 group in the identical position. The trifluoromethyl group is found to induce an inductive effect while the CO2- group is weakly deactivating from the ortho position. As expected the effect of halogens in the meta position is powerfully accelerating. 34 references. In the experiment, the researchers used many compounds, for example, 1-Chloro-3-fluoro-5-nitrobenzene (cas: 4815-64-9Synthetic Route of C6H3ClFNO2).
1-Chloro-3-fluoro-5-nitrobenzene (cas: 4815-64-9) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C6H3ClFNO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics