Design, synthesis, and antibacterial activity of novel myricetin derivatives containing sulfonate was written by Su, Shijun;Zhou, Qing;Tang, Xuemei;Peng, Feng;Liu, Tingting;Liu, Liwei;Xie, Chengwei;He, Ming;Xue, Wei. And the article was included in Monatshefte fuer Chemie in 2021.Product Details of 777-44-6 This article mentions the following:
A series of myricetin derivatives containing sulfonate groups I (R = Ph, 2-chlorophenyl, 2-thienyl, etc.) was designed and synthesized. Preliminary antibacterial activity showed that most of the target compounds I exhibited significant biol. activities against Xanthomonas axonopodis pv. In particular, the EC50 value of compound I (R = 4-nitrophenyl) was 13.76μg/cm3 against Xac, which was better than com. reagents bismerthiazol (50.32μg/cm3) and thiodiazole copper. (83.27μG/cm3), and the EC50 value of compound I (3-chlorophenyl) was 11.92μg/cm3 against Xoo in vitro and the result was better than that of bismerthiazol (72.08μg/cm3) and thiodiazole copper (99.26μg/cm3). Compound I (R = 3-chlorophenyl) displayed the better in vivo activity against rice bacterial leaf blight than bismerthiazol and thiodiazole copper. Meanwhile, the antibacterial mechanism of compounds I (R = 4-nitrophenyl) and I (R = 3-chlorophenyl) was studied by scanning electron microscope (SEM). These results suggested that myricetin derivatives containing sulfonate I can be considered as new antibacterial reagents. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Product Details of 777-44-6).
3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Product Details of 777-44-6
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics