Synthesis and antibacterial activity of novel icariin derivatives was written by Wang, A.;Zhang, Aili;Xu, Y.. And the article was included in Pharmazie in 2019.Synthetic Route of C8H9ClO4S This article mentions the following:
A series of aromatic sulfonyls substituted icariin derivatives I (R = 4-FC6H4, 4-F3CC6H4, 2-thienyl, etc.) was synthesized and their antibacterial activities against S. aureus (including drug-sensitive bacteria and drug-resistant bacteria) were evaluated. Among them, compound I (R = 4-F3CC6H4) exhibited high potency against methicillin-sensitive (MSSA) and resistant strains of S. aureus (MRSA) with MIC values of 1-2 mmol/L. Reverse virtual screening and mol. docking anal. indicated that compound I (R = 4-F3CC6H4) might bind the allosteric site of PBP2a that may inhibit cell wall synthesis, with the advantage of activity against multidrug resistant S. aureus. Surface plasmon resonance (SPR) experiment further confirmed the binding affinity. Therefore, aromatic sulfonyls at C-3 position substituted icariin derivatives have been considered to be a novel class of anti-MRSA agents worth of further investigation. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Synthetic Route of C8H9ClO4S).
2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Synthetic Route of C8H9ClO4S
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics