Palladium-Catalyzed 5-exo-dig Cyclization Cascade, Sequential Amination/Etherification for Stereoselective Construction of 3-Methyleneindolinones was written by Zuo, Youpeng;He, Xinwei;Tang, Qiang;Hu, Wangcheng;Zhou, Tongtong;Hu, Wenbo;Shang, Yongjia. And the article was included in Advanced Synthesis & Catalysis in 2021.Safety of 5-Chloro-2-methoxybenzoic acid This article mentions the following:
An cascade intramol. 5-exo-dig cyclization of N-(2-iodophenyl)propiolamides and sequential amination/etherification (with N-hydroxybenzamides, Ph hydroxycarbamate) protocol for the synthesis of amino- and phenoxy-substituted 3-methyleneindolinones I [R = Ph, 2-naphthyl, 2-thienyl, etc.; R1 = H, 6-Me, 7-Cl, etc.; R2 = Me, Et, Ph, OPh; R3 = Me, Et, allyl, Bn] using unexpensive Pd(PPh3)4 as catalyst was developed. The protocol enabled the assembly of structurally important oxindole cores featuring moderate functional group tolerance (particularly the halo group), affording a broad spectrum of products with diverse substituents in good to excellent yields. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Safety of 5-Chloro-2-methoxybenzoic acid).
5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Safety of 5-Chloro-2-methoxybenzoic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics