The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection was written by Xiong, Yusheng;Wiltsie, Judyann;Woods, Andrea;Guo, Jian;Pivnichny, James V.;Tang, Wei;Bansal, Alka;Cummings, Richard T.;Cunningham, Barry R.;Friedlander, Arthur M.;Douglas, Cameron M.;Salowe, Scott P.;Zaller, Dennis M.;Scolnick, Edward M.;Schmatz, Dennis M.;Bartizal, Kenneth;Hermes, Jeffrey D.;MacCoss, Malcolm;Chapman, Kevin T.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Reference of 1138-56-3 This article mentions the following:
A potent and selective anthrax LF inhibitor (I) , was identified through SAR study of a high throughput screen lead. It has an IC50 of 54 nM in the enzyme assay and an IC50 of 210 nM in the macrophage cytotoxicity assay. I is also effective in vivo in several animal model studies and is orally bioavailable in dogs and rhesus monkey. In combination with ciprofloxacin I significantly increases the survival rate of mice and rabbits treated with anthrax. I is even effective prophylactically in preventing anthrax infection in spore challenges without antibiotics. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Reference of 1138-56-3).
4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Reference of 1138-56-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics