Recoverable and Reusable V2O5/SnO2 catalyst for N-Boc protection of amines under solvent-free conditions was written by Ramchander, Potu;Raju, Gugulothu Vijayacharan Gajula;Satyanaryana, Battu. And the article was included in Journal of Chemical and Pharmaceutical Research in 2017.Safety of tert-Butyl (4-chlorophenyl)carbamate This article mentions the following:
A simple methodol. for the synthesis of N-aryl carbamates RNBoc [R = Ph, 2-MeC6H4, 2-H2NC6H4, etc.] via N-Boc protection of amines using V2O5/SnO2 catalyst was developed. The reactions proceeded smoothly under solvent-free conditions and N-Boc protection of amines were obtained in good to excellent yields. This heterogeneous catalysis offered the advantages such as ease to prepare the V2O5/SnO2 catalyst, low cost, availability and reusability of the catalyst, avoid to use of base-, metal-, or acid-reagents, relatively short reaction times and clean workup and no side reactions. The catalyst could be easily recovered and reused for ten reaction cycles for protection of amines without considerable loss of activity and yields. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Safety of tert-Butyl (4-chlorophenyl)carbamate).
tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Safety of tert-Butyl (4-chlorophenyl)carbamate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics