CON4EI: Selection of the reference chemicals for hazard identification and labelling of eye irritating chemicals was written by Adriaens, E.;Alepee, N.;Kandarova, H.;Drzewieckac, A.;Gruszka, K.;Guest, R.;Willoughby, J. A. Sr.;Verstraelen, S.;Van Rompay, A. R.. And the article was included in Toxicology In Vitro in 2017.SDS of cas: 96568-04-6 This article mentions the following:
Assessment of the acute eye irritation potential is part of the international regulatory requirements for testing of chems. In the past, several prospective and retrospective validation studies have taken place in the area of serious eye damage/eye irritation testing. Success in terms of complete replacement of the regulatory in vivo Draize rabbit eye test has not yet been achieved. A very important aspect to ensure development of successful alternative test methods and/or strategies for serious eye damage/eye irritation testing is the selection of appropriate reference chems. A set of 80 reference chems. was selected for the CEFIC-LRI-AIMT6-VITO CON4EI (CONsortium for in vitro Eye Irritation testing strategy) project, in collaboration with Cosmetics Europe, from the Draize Reference Database published by Cosmetics Europe based on key criteria that were set in their paper (e.g. balanced by important driver of classification and phys. state). The most important goals of the CON4EI project were to identify the performance of eight in vitro alternative tests in terms of driver of classification and to identify similarities/differences between the methods in order the build a successful testing strategy that can discriminate between all UN GHS categories. This paper provides background on selection of the test chems. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6SDS of cas: 96568-04-6).
Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.SDS of cas: 96568-04-6
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics