Radiohalogen-labeled imaging agents. 3. Compounds for measurement of brain blood flow by emission tomography was written by Sargent, Thornton III;Shulgin, Alexander T.;Mathis, Chester A.. And the article was included in Journal of Medicinal Chemistry in 1984.HPLC of Formula: 90064-48-5 This article mentions the following:
3-(4-[131I]iodo-2,5-dimethoxyphenyl)isopropylamines I (R1 = alkyl, NH2, OH, CH2CN, CH2CH2SH, PhCH2, etc.; R2 = H, Me, or Et) were prepared by reductive amination of 3-(4-[131I]iodo-2,5-dimethoxyphenyl)-2-propanone and evaluated for measurement of brain blood flow by emission tomog. Parameters investigated were the percent of injected dose appearing in the brain or other organs and the ratio of organ/blood radioactivity normalized on a weight basis, and since it is desirable that optimal values be reached within a few 1/2 lives, data were obtained at 5 and 30 min for each compound In rats, 3-(4-[131I]iodo-2,5-dimethoxyphenyl)-N,N-dimethylisopropylamine (I; R1 = R2 = Me), prepared in a matter of s, with a chem. yield and radioactive purity both >90%, had the highest percent uptake in brain, 3.4%, and the highest value of brain/blood ratio, 9.0. In dog this compound reached maximum activity in the brain at 5 min and decreased to 65% of its maximum value by 30 min. In the experiment, the researchers used many compounds, for example, 4-Chloro-2,5-dimethoxybenzaldehyde (cas: 90064-48-5HPLC of Formula: 90064-48-5).
4-Chloro-2,5-dimethoxybenzaldehyde (cas: 90064-48-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.HPLC of Formula: 90064-48-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics