Ultrasound promoted environmentally benign, highly efficient, and chemoselective N-tert-butyloxycarbonylation of amines by reusable sulfated polyborate was written by Pise, Ashok A.;Ingale, Ajit P.;Dalvi, Navnath R.. And the article was included in Synthetic Communications in 2021.Formula: C11H14ClNO2 This article mentions the following:
The sulfated polyborate catalyzed an efficient and chemoselective N-tert-butyloxycarbonylation of amines RNHR1 [R = n-Bu, cyclohexyl, Ph, Bn, etc.; R1 = H, Et; RR1 = -(CH2)2O(CH2)2-, -(CH2)5-] under ultrasonic irradiation is developed. A broad substrate scope has been demonstrated for N-Boc protection of various primary/secondary amines. It allows converting several aliphatic/aryl/heteroaryl amines, amino alc., aminoester, and chiral amines to their N-Boc-protected derivatives RN(R1)C(O)OC(CH3)3 under solvent-free conditions with excellent yields. The protocol has several advantages such as easy catalyst, product isolation, short reaction time, excellent yields, outstanding chemoselectivity, and catalyst recyclability, among others. This makes the process practicable, economical, and environmentally benign. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Formula: C11H14ClNO2).
tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Formula: C11H14ClNO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics