Synthesis and structure-activity relationships of new arylfluoronaphthyridine antibacterial agents was written by Chu, Daniel T. W.;Fernandes, Prabhavathi B.;Claiborne, Akiyo K.;Gracey, Eugene H.;Pernet, Andre G.. And the article was included in Journal of Medicinal Chemistry in 1986.Reference of 96568-04-6 This article mentions the following:
The aminonaphthyridinecarboxylic acids I (R = H, 4-F, 2,4-F2, R1R2N = piperazino, 3-hydroxypyrrolidino, 3- and 4-methylpiperazino, 3-aminopyrrolidino) were prepared from Et 2,6-dichloro-5-fluoro-3-pyridinecarboxylate via cyclization of the esters II. The in vitro antibacterial activity is greatest for I (R = 4-F, 2,4-F2; R1R2N = 3-aminopyrrolidino). In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Reference of 96568-04-6).
Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 96568-04-6
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics