Simple Synthesis of Fused Thiazolo[4,5-b]pyridines through Successive SN Ar Processes was written by Starosotnikov, Alexey M.;Bastrakov, Maxim A.;Kachala, Vadim V.;Fedyanin, Ivan V.;Klimova, Tatyana A.;Ivanova, Victoria V.;Dalinger, Igor L.. And the article was included in Synlett in 2021.Application of 59237-53-5 This article mentions the following:
A convenient process is described for the synthesis of novel thiazolo[4,5-b]pyridines fused with triazole or pyrimidine rings. The base-promoted reactions of 2-chloro-3-nitropyridines with 1,3-( S, N)-binucleophiles (triazole-5-thiols, 4-oxopyrimidine-2-thiones) resulted in nucleophilic substitution of the chlorine atom and subsequent S-N-type Smiles rearrangement followed by nucleophilic substitution of the nitro group. Reactions with pyrimidine-2-thiones were carried out as one-pot processes while, in the case of triazole-5-thiols, isolation of intermediate substitution products was found to be preferable. In the experiment, the researchers used many compounds, for example, Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5Application of 59237-53-5).
Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application of 59237-53-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics