Synthesis, spectral characterization, docking studies and biological activity of urea, thiourea, sulfonamide and carbamate derivatives of imatinib intermediate was written by Chandrasekhar, Mandala;Prasad, Gandavaram Syam;Venkataramaiah, Chintha;Naga Raju, Chamarthi;Seshaiah, Kalluru;Rajendra, Wudayagiri. And the article was included in Molecular Diversity in 2019.HPLC of Formula: 777-44-6 This article mentions the following:
A series of new urea/thiourea derivatives I [R = 4-Cl, 3-Cl, 4-Br, 4-NO2, 2,4-di-F; X = O; R = H, 4-F, 3-Cl, 3-Br, 3-CF3; X = S] was synthesized by simple addition reaction of functionalized Ph isocyanates/isothiocyanates with N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinamine (imatinib intermediate) in the presence of 1,4-di-Me piperazine (DMPZ) as a base and another series of new sulfonamide derivatives II [R1 = 4-FC6H4, 4-O2NC6H4, 3-F3CC6H4, etc.] and carbamate derivatives III [R2 = CH2CH(CH3)2, CH2CCl3, 4-ClC6H4, etc.] were synthesized by reacting imatinib intermediate with various substituted aromatic sulfonyl chlorides and aromatic/aliphatic chloroformates in the presence of DMPZ as a base. Antimicrobial, antioxidant and in silico mol. docking studies were made against aromatase. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6HPLC of Formula: 777-44-6).
3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 777-44-6
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics