Reactivity of N-chloro-substituted sulfonamides was written by Verma, Shiva M.;Srivastava, Ramesh C.. And the article was included in Indian Journal of Chemistry in 1966.Related Products of 14070-51-0 This article mentions the following:
The behavior of N-chloro-N-acyl- and N-chloro-N-aroyl-p-toluenesulfonamides in protonic and aprotic solvents was investigated. N-Acetyl- and N-benzoyl-p-toluenesulfonamides were prepared by acetylation (Ac2O and concentrated H2SO4) and benzoylation of p-MeC6H4SO2NH2, resp. N-Benzyl derivatives were obtained by the condensation of PhCH2NH2 with p-MeC6H4SO2Cl. The N-chloro derivatives were prepared by the action of excess HOCl on N-substituted p-toluenesulfonamides as described earlier (CA 63, 11421a); they could also be prepared by passing Cl into sodium salts of the parent sulfonamides. The following were prepared: N-chlorosaccharin, m. 152°: N-acetyl (benzyl and benzoyl)-N-chloro-p-toluenesulfonamides, m. 68°, 106°, and 96-8°, resp. All the N-chloro derivatives were crystalline compounds N-Chloro-N-acetyl derivatives in EtOH (with or without HCl) and in HOAc-H2SO4 media gave p-MeC6H4SO2NH2 and HOAc. The corresponding benzoyl derivatives in EtOH yielded the parent sulfonamide; in HOAc-H2SO4 medium the products formed were BzOH and p-MeC6H4SO2NH2. N-Chloro-N-benzoyl-p-toluenesulfonamide was stable toward these solvents. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Related Products of 14070-51-0).
2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 14070-51-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics